Antimetastatic activity of a cyclooxygenase-2 inhibitor
نویسندگان
چکیده
منابع مشابه
The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor on Noise- Induced Hearing Loss
Objective(s): Noise-induced hearing loss (NIHL) is the major cause of acquired hearing loss. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is a non- steroidal anti- inflammatory drug (NSAID) with known antioxidant and antineoplastic activity. Therefore, we monitored the extent of temporary noise- induced threshold shifts (TTS) and cochlear damage caused by high level 4- kHz noise exposure t...
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Matrix metalloproteinases (MMPs), and in particular gelatinases (MMP-2 and MMP-9), play a key role in cancer progression. However, clinical trials in which MMP inhibitors were tested in cancer patients have been disappointing. Whereas many reasons have been postulated to explain the failure of the clinical trials, lack of inhibitor selectivity was a major limitation. Thus, despite the consensus...
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متن کاملthe effect of celecoxib, a cyclooxygenase-2 inhibitor on noise- induced hearing loss
objective(s): noise-induced hearing loss (nihl) is the major cause of acquired hearing loss. celecoxib, a cyclooxygenase-2 (cox-2) inhibitor, is a non- steroidal anti- inflammatory drug (nsaid) with known antioxidant and antineoplastic activity. therefore, we monitored the extent of temporary noise- induced threshold shifts (tts) and cochlear damage caused by high level 4- khz noise exposure t...
متن کامل[Specific cyclooxygenase-2 inhibitor analgesics: therapeutic advances.].
BACKGROUND AND OBJECTIVES Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are among the most widely prescribed drugs, including for Anesthesiology. This review aimed at discussing some current cycloxygenase biochemical aspects, which have provided the basis for the development of new analgesic and anti-inflammatory drugs. CONTENTS These drugs primarily act by inhibiting cycloxygenase (COX), whi...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2004
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6601967